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How could the utilization of chromatography sorbents be improved?

How to create an improved process to more efficiently use sorbents in multicolumn-chromatography-based downstream manufacturing.

Pall and CMC Biologics pave the way with multicolumn-chromatography-based downstream manufacturing

The Problem:

To cope with the increasing demand on downstream processing (DSP), chromatography columns generally must be cycled multiple times, creating additional holding time when the load material is not being processed. As such, the biopharmaceutical industry would benefit greatly from an improved process to more efficiently use the sorbents (i.e. capture step or polishing unit operations).

 

The Solution:

Multi-column chromatography (MCC) technology offers prominent productivity gains and economic advantages for DSP. Despite the upfront capital expenses required for adopting MCC technology, the significant cost savings achieved from sorbent reduction and productivity improvement make it a justifiable investment, which benefits drug developers of any kind in the long run. CMC Biologics is one of first CDMOs to offer multi-column chromatography using Cadence™ BioSMB systems to their customers.

Immediate results have included reduced clinical manufacturing costs through improved sorbent utilization.

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Development of a Scalable Viral Vector Upstream Process for Gene Therapy

Genethon and Pall® Biotech have collaborated to demonstrate the benefits of the iCELLis® fixed-bed bioreactor as a platform for viral vector production.
Genethon and Pall® Biotech have collaborated to demonstrate the benefits of the iCELLis® fixed-bed bioreactor as a platform for viral vector production.
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How could the utilization of chromatography sorbents be improved?

Pall and CMC Biologics Pave the Way with Multicolumn-Chromatography-based Downstream Manufacturing.
Pall and CMC Biologics Pave the Way with Multicolumn-Chromatography-based Downstream Manufacturing.
Learn More

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What was putting a choke-hold on sterile filtration throughput? Spanish CMO Unolab switched to Pall’s polyethersulfone membrane filters and solved a challenging issue.
What was putting a choke-hold on sterile filtration throughput? Spanish CMO Unolab switched to Pall’s polyethersulfone membrane filters and solved a challenging issue.
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Single-Use Technologies In A 1000 Liter Plus Monoclonal Antibody Process

How to confirm that single-use manufacturing is feasible for mAb processes at a 1,000-liter plus scale? Pall helped Rentschler to find the answers.
How to confirm that single-use manufacturing is feasible for mAb processes at a 1,000-liter plus scale? Pall helped Rentschler to find the answers.
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Column Packing - Changing Art To Science

A multinational vaccine company noted that creep in standard operating procedure (SOP) execution and operator error was significantly affecting productivity. Could a column packing success rate of 62% be improved and labor costs reduced?
A multinational vaccine company noted that creep in standard operating procedure (SOP) execution and operator error was significantly affecting productivity. Could a column packing success rate of 62% be improved and labor costs reduced?
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