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New Product Introduction: Allegro™ Fully Automated, Single-Use Chromatography System

December 1, 2017

A flexible system designed for pilot scale, clinical production batches and commercial production.

The Allegro™ single-use chromatography system is the latest addition to the Pall portfolio of automated single-use systems for downstream processing. The flexible system design enables installation of two different size manifolds, conferring maximum flow rates of 500 and 900 L/h respectively. The system includes all the critical process instrumentation for operation and monitoring bio-chromatography processes with disposable or conventional columns (10 – 60 cm diameter). The Allegro SUTFF and MVP systems share the same common automation platform.

 

Allegro single-use chromatography system key features:

·       Choice of single-use sensors

·       Pressure, flow, conductivity, pH, temperature, UV

·       Unique pinch block valves design

·       Easy manifold installation and column connection

·       Isocratic or gradient configuration

·       Multimodal chromatography - Sorbents and membrane chromatography

·       Accommodate ⅜ in. and ½ in. manifolds on one system

·       Low hold system hold up volume 0.5 L (⅜ in. manifold) and 1L (½ in. manifold)

·       Column coverage 10 – 60 cm diameter

·       4 bar max operating pressure

·       6 inlets (per pump) and 4 outlets

·       Pall process step editor software

·       Manual or full automation control

·       CFR21 Part 11 compliant

·       Data and event logging

·       Batch report generator

·       Calculation of key process indicators

·       cGMP compliant design and documentation

·       Flexibility to connect a range of totes and mixers to the system

·       No calibration of single use sensors

·       Gamma sterile manifold sets (25 kGy)

·       Connections for two external load cells

·       Reliable, robust operation 

A flexible system designed for pilot scale, clinical production batches and commercial production.