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Membrane Chromatography

Single-use chromatography solution to purify viral vectors and remove impurities from therapeutic proteins

Why Membrane Adsorbers?

Chromatography membranes combine ion exchange chemistry with the high flow and processing simplicity of pre-packaged capsules. The high surface area and large pore sizes provide high dynamic binding capacities, especially for large molecules and particles, and are easily incorporated into a process for the removal of impurities or for the purification of select molecules (coagulation factors) or viral vectors (AAV, Lentivirus). The range of scalable formats available allows them to be used in a variety of purification processes, from laboratory to manufacturing scale.

 

The benefits of membrane chromatography include:

 

  • High binding efficiency due to direct access to the binding groups, even at high flow rates
  • Speed – high flow rates enable the processing of large volumes. As an example, Pall Mustang® capsules typically operate at a flow rate of 10 membrane volumes (MV) per minute, which equates to 50 L per minute for the largest capsule format. This flowrate is 20 to 50 times faster than conventional chromatography sorbents
  • Scalability and flexibility – a wide range of capsule sizes accommodates various volumes and capacities
  • Ready-to-use – the capsule format eliminates the need for packing and unpacking. If used as part of a single-use manufacturing process, there are no cleaning or cross-contamination issues
  • Lower cost of operation – membrane capsules offer lower operating and capital investment costs than conventional columns that require packing
  • Reduced buffer consumption – small device footprint requires significantly less buffer

Applications

Therapeutic Proteins: membrane adsorbers are frequently used in the production of monoclonal antibodies (mAbs) for the removal of DNA and host cell proteins (HCPs) to comply with regulatory end-product requirements.

 

3317 cover image

A Universal Streamlined Three-Step Chromatography Platform for Monoclonal Antibody Purification

 

Gene Therapy: new solutions to purify industrial relevant quantities of viral vectors are required to support the rapid growth in the treatment of genetic diseases. The unique properties of single-use membrane chromatography, such as Pall Mustang Q anion exchange membrane efficiently contribute to the purification of viral vectors such as lentivirus (LV) and adeno-associated virus (AAV) in compliance with cGMP requirements.

 

gene therapy white paper cover image

An end-to-end process for large-scale adenovirus manufacturing for gene therapy

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Pall’s Mustang Q anion exchange membrane is a proven chromatography membrane product, available in a variety of different formats, with excellent demonstrated scalability. The multi-layer membrane construction is held at constant thickness/bed depth, from small scale to the largest industrial process-scale capsule. Additionally, Mustang membrane chromatography devices are more compact than conventional beaded sorbents, providing significant savings in buffer volume requirements and footprint.

 

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